When Dante first enters the tower, Cerberus demands he leave, and then attacks when Dante mocks him. After being defeated, Cerberus willingly relinquishes his soul to Dante as a Devil Arm.
The Gigapede is a giant tapeworm-like demon who entered the Human world through a time-space rift. It possesses a strong exoskeleton that impedes enemy attacks, and can generate ball-lightning to deter foes.One Gigapede defends the Incandescent Space in the ground floors of the Temen-ni-gru, while two others inhabit Leviathan's intestines.
Jester is Arkham's alter ego. In this persona, Jester frequently taunts Dante, but occasionally provides helpful hints and tips to him. In the Special Edition of Devil May Cry 3, Jester can be fought as a semi-optional enemy. (The first encounter with him in Mission 5 is mandatory; the other two encounters, which are more difficult, are not.)
Twin Demon gatekeepers of Temen-ni-gru sealed away by Sparda, Agni and Rudra are a pair of living swords, swung by demon hosts, searching for an owner worthy of their power. Agni is the red sword with power to control fire, while Rudra is the blue sword with power to control wind. They are adept at fighting together, though they can be tricked into hurting each other.The easiest way to defeat them is to damage both at the same time, so that when one falls, the other falls just as easily. However, once one host is defeated, the other will go for the fallen sword, allowing him to become more powerful.
The brothers are at first cordial to Dante, discussing how to be "gracious hosts", but when he demands to be let through their gate, they attack. After Dante defeats them, they ask to be taken with him as Devil Arms, and Dante agrees on the condition that they remain quiet.
One of the gatekeepers of Temen-ni-gru sealed away by Sparda, Nevan is a Leanashe who seduces men down the path to hell. She fights with a combination of lightning and her bats which defend and attack for her. She is also able to latch onto Dante and suck his soul out through his mouth.
Dante meets her on his path down to the Lair of Judgement. When he enters Sunken Opera House, they flirt and then begin to fight. Dante defeats her, and she relinquishes her soul to Dante as a Devil Arm.
One of the gatekeepers of Temen-ni-gru, half-blinded and sealed away for 2000 years by Sparda, Beowulf is a winged beast who anxiously awaits his chance at revenge. He possesses overwhelming strength and a variety of light attacks.
When Dante enters Beowulf's chamber, he senses that Dante has "Sparda's blood", and attacks. Dante defeats and blinds Beowulf, but when Beowulf tries to chase down Sparda's scent he instead finds Vergil. Assuming him to still be Dante, he tries to "annihilate every last blood relation of Sparda". However, Vergil immediately kills Beowulf and the demon falls apart, realizing his mistake. Vergil then takes Beowulf's soul as a Devil Arm. Dante later obtains it after Arkham activates the Temen-ni-gru and Vergil falls into an abyss.
Geryon was once a horse of legend ridden by countless heroes, until ingesting demonic essence corrupted and empowered him with limited control over time. He leads a ghostly hearse, equipped with a heavy armament.
When Dante first steps upon Geryon's bridge, Geryon engages him in a game of "Chicken" until the bridge collapses and they fall into a Colosseum-style arena. After Dante defeats Geryon, Dante receives his soul as an attack Style.
Doppelganger is a malevolent shadow demon able to take the shape of its foe by refracting light. As a being of shadow, however, it can be paralyzed by shining light on it. In shadow, it imitates Dante's Rebellion Devil Trigger, while in light it resembles Dante himself.
When Dante first enters Doppelganger's lair, Dante mocks him for trying to "ask [him] some questions", saying that he's already answered them to himself. After defeating Doppelganger, Dante receives its soul as an attack Style.
The apparent new god has now transformed into this gruesome beast after obtaining the power of Sparda. With this transformation, he has gained control over legions of slug-like creatures, as well as a few melee attacks which can cause immense damage. Ironically, this transformation was not a result of the induction of Sparda's powers, but rather, comes from the malevolence found in Arkham's heart.
